Marizza, Paolo3; Keller, Stephan Sylvest3; Rades, T.4; Müllertz, A.4; Kikic, I.5; Moneghini, M.5; De Zordi, N.5; Solinas, D.5; Boisen, Anja3
1 Department of Micro- and Nanotechnology, Technical University of Denmark2 Nanoprobes, Department of Micro- and Nanotechnology, Technical University of Denmark3 Center for Intelligent Drug Delivery and Sensing Using Microcontainers and Nanomechanics, Center, Technical University of Denmark4 University of Copenhagen5 University of Trieste
In this work we present an effective loading technique of micro-containers for oral drug delivery of a poorly water soluble drug in a solid dispersion with polymer. By combining inkjet printing and supercritical CO2 impregnation we load ketoprofen in a solid dispersion with poly(vinylpyrrolidone) (PVP) into cylindrical micro-containers providing unidirectional release. Both the printing and the impregnation step can be tuned in order to control drug loading with accuracy in the range of micro-grams.
Proceedings of the 40th Annual Meeting & Exposition of the Controlled Release Society, 2013
Main Research Area:
40th Annual Meeting & Exposition of the Controlled Release Society, 2013