In this work we present an effective loading technique of micro-containers for oral drug delivery of a poorly water soluble drug in a solid dispersion with polymer. By combining inkjet printing and supercritical CO2 impregnation we load ketoprofen in a solid dispersion with poly(vinylpyrrolidone) (PVP) into cylindrical micro-containers providing unidirectional release. Both the printing and the impregnation step can be tuned in order to control drug loading with accuracy in the range of micro-grams.
Proceedings of the 40th Annual Meeting & Exposition of the Controlled Release Society, 2013
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40th Annual Meeting & Exposition of the Controlled Release Society, 2013