1 Department of Clinical Medicine - The Department of Dermatology and Venereology, Department of Clinical Medicine, Health, Aarhus University2 University Medical Centre Hamburg-Eppendorf, Institute for Health Services Research in Dermatology & Nursing, Hamburg, Germany.3 unknown4 Department of Clinical Medicine - The Department of Dermatology and Venereology, Department of Clinical Medicine, Health, Aarhus University
Development and Validation of a Tool for Assessment of Nail Psoriasis Outcomes
BACKGROUND: Existing tools for nail psoriasis are complex and may not adequately measure outcomes that are important to patients. OBJECTIVES: We have developed and validated a new tool, the Nail Assessment in Psoriasis and Psoriatic Arthritis (NAPPA), with three components: a questionnaire assessing quality of life (NAPPA-QoL), a two-part questionnaire assessing patient-relevant treatment benefits (the Patient Benefit Index, NAPPA-PBI) and a psoriasis Clinical Assessment of Severity (NAPPA-CLIN). METHODS: Development of the questionnaires involved multiple steps: (i) collection of items about nail psoriasis-related impairments and treatment goals; (ii) selection of 48 items by an expert panel, including patients; (iii) translation into eight languages; (iv) feasibility testing and (v) longitudinal validation in six countries. RESULTS: Patients found the questionnaires clear (84%) and comprehensible (95%). NAPPA-QoL and NAPPA-PBI scores correlated moderately with clinical outcomes [e.g. Nail Psoriasis Severity Index (NAPSI)] and markedly with other quality-of-life questionnaires (e.g. EQ-5D™). Both questionnaires were sensitive to change. Internal consistency was good (Cronbach α ≥ 0.88 for all scales). The NAPPA-CLIN, a brief version of NAPSI that involves assessment of only four digits rather than all 20, was found to correlate highly with total NAPSI score (r = 0.97, P < 0.001). CONCLUSIONS: Overall, the three-component NAPPA tool is a valid, reliable and practical instrument to assess patient-relevant nail psoriasis outcomes.
British Journal of Dermatology, 2013, Vol 170, Issue 3, p. 591-8
Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't; Validation Studies; Adult; Aged; Aged, 80 and over; Arthritis, Psoriatic; Feasibility Studies; Female; Humans; Male; Middle Aged; Nail Diseases; Patient Outcome Assessment; Patient Satisfaction; Psoriasis; Quality of Life; Treatment Outcome; Young Adult