Ganz, Melanie3; Sabuncu, M. R.3; Van Leemput, Koen1
1 Department of Applied Mathematics and Computer Science, Technical University of Denmark2 Image Analysis & Computer Graphics, Department of Applied Mathematics and Computer Science, Technical University of Denmark3 Harvard Medical School
In this paper, we will re-visit the Relevance Voxel Machine (RVoxM), a recently developed sparse Bayesian framework used for predicting biological markers, e.g., presence of disease, from high-dimensional image data, e.g., brain MRI volumes. The proposed improvement, called IRVoxM, mitigates the shortcomings of the greedy optimization scheme of the original RVoxM algorithm by exploiting the form of the marginal likelihood function. In addition, it allows voxels to be added and deleted from the model during the optimization. In our experiments we show that IRVoxM outperforms RVoxM on synthetic data, achieving a better training cost and test root mean square error while yielding sparser models. We further evaluated IRVoxM’s performance on real brain MRI scans from the OASIS data set, and observed the same behavior - IRVoxM retains good prediction performance while yielding much sparser models than RVoxM.
Lecture Notes in Computer Science: 4th International Workshop, Mlmi 2013, Held in Conjunction With Miccai 2013, Nagoya, Japan, September 22, 2013. Proceedings, 2013, p. 147-154
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Lecture Notes in Computer Science
16th International Conference on Medical Image Computing and Computer Assisted Intervention (MICCAI 2013) : 4th International Workshop on Machine Learning in Medical Imaging (MLMI 2013)Medical Image Computing and Computer Assisted Intervention