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The cell-free fetal DNA fraction in maternal blood decreases after physical activity

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Authors:
  • Schlütter, Jacob Mørup ;
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    Aarhus Universitetshospital
  • Hatt, Lotte ;
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    Department of Genetics, Institute of Regional Health Research, Faculty of Health Sciences, SDU
  • Bach, Cathrine ;
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    unknown
  • Kirkegaard, Ida ;
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    unknown
  • Kølvraa, Steen ;
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    Center Lillebaelt, Institute of Regional Health Research, Faculty of Health Sciences, SDU
  • Uldbjerg, Niels
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    unknown
DOI:
10.1002/pd.4306
Abstract:
OBJECTIVE: If noninvasive prenatal testing using next generation sequencing is to be effective for pregnant women, a cell-free fetal DNA (cffDNA) fraction above 4% is essential unless the depth of sequencing is increased. This study's objective is to determine whether physical activity has an effect on the proportion of cell-free DNA (cfDNA) arising from the fetus (fetal fraction). METHODS: Nine pregnant women carrying male fetuses at gestational age 12(+0)  weeks to 14(+6)  weeks were included. Plasma from nine pregnant women was drawn prior to, immediately after, and 30 min after 30 min of cycling with a pulse-rate of 150 beats per minute. The concentrations of cffDNA (DYS14) and cfDNA (RASSF1A) were assessed using quantitative real-time polymerase chain reaction. RESULTS: The fetal fraction decreased significantly in all participants after physical activity (p < 0.01), a decrease varying from 1-17 percentage points. This was due to a significant increase in the concentration of cfDNA (p < 0.01), whereas the concentration of cffDNA remained the same. This alteration of the fetal fraction was not present 30 min after physical activity. CONCLUSION: When planning the timing of noninvasive prenatal diagnosis based on the fetal fraction, physical activity prior to sampling should be avoided.
Type:
Journal article
Language:
English
Published in:
Prenatal Diagnosis, 2014, Vol 34, Issue 4, p. 341-4
Main Research Area:
Medical science
Publication Status:
Published
Review type:
Peer Review
Submission year:
2014
Scientific Level:
Scientific
ID:
261064596

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