1 Molecular Physiology, Department of Nutrition, Exercise and Sports, Faculty of Science, Københavns Universitet2 Department of Endocrinology, Odense University Hospital and Section of Molecular Diabetes and Metabolism, Institute of Clinical Research, University of Southern Denmark, Odense3 Department of Clinical Genetics, Odense University Hospital, Odense4 Institute of Sports Science and Clinical Biomechanics, SDU Muscle Research Cluster (SMRC), University of Southern Denmark, Odense5 Department of Endocrinology, Odense University Hospital, Odense6 Molecular Physiology, Department of Nutrition, Exercise and Sports, Faculty of Science, Københavns Universitet
Insulin resistance in obesity and type 2 diabetes is related to abnormalities in mitochondrial oxidative phosphorylation (OxPhos) in skeletal muscle. We tested the hypothesis that mitochondrial oxidative metabolism is impaired in muscle of patients with inherited insulin resistance and defective insulin signalling.
Diabetologia, 2014, Vol 57, Issue 5, p. 1006-1015
Adult; Antigens, CD; Case-Control Studies; Family Health; Female; Heterozygote; Humans; Insulin Resistance; Male; Middle Aged; Mitochondria; Muscle, Skeletal; Mutation; Oligonucleotide Array Sequence Analysis; Oxidative Phosphorylation; Oxygen; Phosphorylation; Protein Structure, Tertiary; Receptor, Insulin; Signal Transduction; Transcription Factors; Transcription, Genetic; Young Adult