Capasso, Mario2; Calabrese, Francesco Maria2; Iolascon, Achille2; Mellerup, Erling4
1 Department of Neuroscience and Pharmacology, Faculty of Health and Medical Sciences, Københavns Universitet2 unknown3 Neuropsyk Lab, Department of Neuroscience and Pharmacology, Faculty of Health and Medical Sciences, Københavns Universitet4 Neuropsyk Lab, Department of Neuroscience and Pharmacology, Faculty of Health and Medical Sciences, Københavns Universitet
Analysis of combinations of genetic changes that occur exclusively in patients may be a supplementary strategy to the single-locus strategy used in many genetic studies. The genotypes of 16 SNPs within susceptibility loci for neuroblastoma (NB) were analyzed in a previous study. In the present study, combinations of these genotypes have been analyzed. The theoretical number of combinations of 3 SNP genotypes taken from 16 SNPs is 15,120. Of these, 14,307 were found in 370 patients and 803 controls; 12,772 combinations were common to both patients and controls; 1,213 were found in controls only; and 322 combinations were found in patients only. Among the latter, a cluster of 24 combinations was found to be significantly associated with NB (P < 0.00001).
Cancer Genetics, 2014, Vol 207, Issue 3, p. 94-7
Genotype; Humans; Neuroblastoma; Polymorphism, Single Nucleotide