Chadha, Preet S2; Jepps, Thomas A4; Carr, Georgina3; Stott, Jennifer B3; Zhu, Hei-Lei3; Cole, William C3; Greenwood, Iain A4
1 Section of Heart and Circulatory Research, Department of Biomedical Sciences, Faculty of Health and Medical Sciences, Københavns Universitet2 From the Division of Biomedical Sciences, Pharmacology and Cell Physiology Research Group, St George's University of London, London, United Kingdom (P.S.C., T.A.J., G.C., J.B.S., I.A.G.); and The Smooth Muscle Research Group, Department of Physiology and Pharmacology, Faculty of Medicine, University of Calgary, Calgary, Alberta, Canada (H.-L.Z., W.C.C.).3 unknown4 Section of Heart and Circulatory Research, Department of Biomedical Sciences, Faculty of Health and Medical Sciences, Københavns Universitet
Middle cerebral artery (MCA) diameter is regulated by inherent myogenic activity and the effect of potent vasodilators such as calcitonin gene-related peptide (CGRP). Previous studies showed that MCAs express KCNQ1, 4, and 5 potassium channel genes, and the expression products (Kv7 channels) participate in the myogenic control of MCA diameter. The present study investigated the contribution of Kv7.4 and Kv7.5 isoforms to myogenic and CGRP regulation of MCA diameter and determined whether they were affected in hypertensive animals.
Arteriosclerosis, Thrombosis, and Vascular Biology, 2014, Vol 34, Issue 4, p. 887-93