The association between low birthweight (LBW) and risk of developing type 2 diabetes may involve epigenetic mechanisms, with skeletal muscle being a prime target tissue. Differential DNA methylation patterns have been observed in single genes in muscle tissue from type 2 diabetic and LBW individuals, and we recently showed multiple DNA methylation changes during short-term high-fat overfeeding in muscle of healthy people. In a randomised crossover study, we analysed genome-wide DNA promoter methylation in skeletal muscle of 17 young LBW men and 23 matched normal birthweight (NBW) men after a control and a 5 day high-fat overfeeding diet.
Diabetologia, 2014, Vol 57, Issue 6, p. 1154-1158
Adult; DNA (Cytosine-5-)-Methyltransferase; DNA Methylation; Diabetes Mellitus, Type 2; Diet, High-Fat; Epigenesis, Genetic; Humans; Infant, Low Birth Weight; Insulin Resistance; Male; Muscle, Skeletal; Young Adult; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't