influence on time to detection of cryptorchidism (undescended testes): a Danish nationwide register study
BACKGROUND: Cryptorchidism (undescended testes) is associated with poor male fertility, but can be alleviated and fertility preserved to some degree by early detection and treatment. Here we assess the influence of socio-occupational class, geographical region, maternal age and birth cohort on time to detection and correction of cryptorchidism. METHODS: All boys born in Denmark, 1981 to 1987 or 1988 to 1994, with a diagnosis of cryptorchidism were identified in nationwide registers. The boys were followed for a diagnosis until their 16th birthday. The age at first diagnosis was noted and used as proxy for time to detection of cryptorchidism. Parental employment in the calendar year preceding birth was grouped into one of five socio-occupational classes. Geographical region was defined by place of birth in one of 15 Danish counties. Detection rate ratios of cryptorchidism were analyzed as a function of parental socio-occupational group, county, maternal age and birth cohort by use of Poisson regression. RESULTS: Some 6,059 boys in the early and 5,947 boys in the late cohort received a diagnosis of cryptorchidism. Time to detection was independent of parental socio-occupational group and maternal age but differed slightly between geographical regions. A similar pattern was obtained for surgical correction after a diagnosis. Age at diagnosis decreased by 2.7 years from the early to the late cohort. CONCLUSIONS: These results indicate that childhood socio-occupational inequality in detection and correction of cryptorchidism would play a negligible role in male infertility in a life course perspective. Geographical region may have exerted some influence, especially for the oldest cohort.
B M C Urology, 2014, Vol 14, Issue 1, p. 1-7
Adolescent; Adult; Age Distribution; Child; Child, Preschool; Cohort Studies; Cryptorchidism; Denmark; Early Diagnosis; Employment; Female; Humans; Infant; Infant, Newborn; Male; Maternal Age; Middle Aged; Prevalence; Registries; Risk Factors; Social Class; Socioeconomic Factors; Spatio-Temporal Analysis; Time Factors; Young Adult; Journal Article; Research Support, Non-U.S. Gov't