OBJECTIVE: The objective of the present study is to describe the prevalence of allostatic load (AL) among Danish men and women in late midlife, and if there is a social gradient in AL. METHOD: A total of 5,420 participants from the Copenhagen Aging and Midlife Biobank (CAMB) aged 48 to 63 years (68.5% men, 31.5% women) underwent a health examination including standardized measures of height, weight, body fat, and blood pressure in 2009-2011. AL (range 0-14) was established by summing the scores of the poorest quartile for each of 14 biological variables related to the metabolic and immune systems. RESULTS: We found a social gradient in AL in late midlife among men and women living in Denmark. DISCUSSION: AL may be a potential biomarker for early aging in countries with a strong social welfare system. It is important for intervention studies to be aware of this type of biological vulnerability already present in late midlife.
Journal of Aging and Health, 2014, Vol 26, Issue 1, p. 72-87
Aging; Allostasis; Biological Markers; Cohort Studies; Denmark; Female; Health Status Disparities; Humans; Male; Middle Aged; Prevalence; Risk Factors; Sex Distribution; Social Class; Journal Article; Research Support, Non-U.S. Gov't