1 Department of Pharmacy, Faculty of Health and Medical Sciences, Københavns Universitet2 Department of Chemistry, Washington State University, Pullman, WA, 99164-4630, USA, email@example.com unknown4 Department of Pharmacy, Faculty of Health and Medical Sciences, Københavns Universitet
intramolecular electron transfer and O2 reduction
The multicopper oxidases are an intriguing, widespread family of enzymes that catalyze the reduction of O2 to water by a variety of single-electron and multiple-electron reducing agents. The structure and properties of the copper binding sites responsible for the latter chemical transformations have been studied for over 40 years and a detailed picture is emerging. This review focuses particularly on the kinetics of internal electron transfer between the type 1 (blue) copper site and the trinuclear center, as well as on the nature of the intermediates formed in the oxygen reduction process.
Journal of Biological Inorganic Chemistry, 2014, Vol 19, Issue 4-5, p. 541-54