Correlation between human papillomavirus and p16 overexpression in oropharyngeal tumours: a systematic review

C Grønhøj Larsen; M Gyldenløve; D H Jensen; M H Therkildsen; Katalin Kiss; B Norrild; L Konge; C von Buchwald

doi:10.1038/bjc.2014.42

Correlation between human papillomavirus and p16 overexpression in oropharyngeal tumours

Authors:

Grønhøj Larsen, C ;
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Department of Oto-rhinolaryngology, Head and Neck Surgery and Audiology, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark.
Gyldenløve, M ;
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Department of Dermato-Allergology, Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark.
Jensen, D H ;
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Morphogenesis and Differentiation Program, Department of Cellular and Molecular Medicine, Faculty of Health and Medical Sciences, Københavns Universitet
Therkildsen, M H ;
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Department of Clinical Medicine, Department of Clinical Medicine, Faculty of Health and Medical Sciences, Københavns Universitet
Kiss, Katalin ;
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unknown
Norrild, B ;
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Morphogenesis and Differentiation Program, Department of Cellular and Molecular Medicine, Faculty of Health and Medical Sciences, Københavns Universitet
Konge, L ;
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0000-0002-1258-5822
Department of Clinical Medicine, Department of Clinical Medicine, Faculty of Health and Medical Sciences, Københavns Universitet
von Buchwald, C
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Department of Clinical Medicine, Department of Clinical Medicine, Faculty of Health and Medical Sciences, Københavns Universitet

Subtitle:

a systematic review

DOI:

10.1038/bjc.2014.42

Abstract:

A significant proportion of squamous cell carcinomas of the oropharynx (OP-SCC) are related to human papillomavirus (HPV) infection and p16 overexpression. This subgroup proves better prognosis and survival but no evidence exists on the correlation between HPV and p16 overexpression based on diagnostic measures and definition of p16 overexpression. We evaluated means of p16 and HPV diagnostics, and quantified overexpression of p16 in HPV-positive and -negative OP-SCCs by mode of immunohistochemical staining of carcinoma cells.

Type:

Journal article

Language:

English

Published in:

B J C, 2014, Vol 110, Issue 6, p. 1587-94

Keywords:

Journal Article; Review

Main Research Area:

Medical science

Publication Status:

Published

Review type:

Peer Review

Submission year:

2014

Scientific Level:

Scientific

ID:

260111048

Correlation between human papillomavirus and p16 overexpression in oropharyngeal tumours

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