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In vivo single-shot (13)C spectroscopic imaging of hyperpolarized metabolites by spatiotemporal encoding

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Authors:
  • Schmidt, Rita ;
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    Department of Chemical Physics, Weizmann Institute of Science, Rehovot, Israel.
  • Laustsen, Christoffer ;
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    Department of Clinical Medicine - The MR Research Centre, Department of Clinical Medicine, Health, Aarhus University
  • Dumez, Jean-Nicolas ;
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    Department of Chemical Physics, Weizmann Institute of Science, Rehovot, Israel.
  • Kettunen, Mikko I ;
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    Department of Biochemistry, University of Cambridge, Cambridge, United Kingdom; Cancer Research UK Cambridge Institute, Li Ka Shing Centre, Cambridge, United Kingdom.
  • Serrao, Eva M ;
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    Department of Biochemistry, University of Cambridge, Cambridge, United Kingdom; Cancer Research UK Cambridge Institute, Li Ka Shing Centre, Cambridge, United Kingdom.
  • Marco-Rius, Irene ;
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    Department of Biochemistry, University of Cambridge, Cambridge, United Kingdom; Cancer Research UK Cambridge Institute, Li Ka Shing Centre, Cambridge, United Kingdom.
  • Brindle, Kevin M ;
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    Department of Biochemistry, University of Cambridge, Cambridge, United Kingdom; Cancer Research UK Cambridge Institute, Li Ka Shing Centre, Cambridge, United Kingdom.
  • Ardenkjaer-Larsen, Jan Henrik ;
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    Danish Research Centre for Magnetic Resonance, Hvidovre Hospital, Denmark; GE Healthcare, Broendby, Denmark.
  • Frydman, Lucio
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    Department of Chemical Physics, Weizmann Institute of Science, Rehovot, Israel. Electronic address: lucio.frydman@weizmann.ac.il.
DOI:
10.1016/j.jmr.2013.12.013
Abstract:
Hyperpolarized metabolic imaging is a growing field that has provided a new tool for analyzing metabolism, particularly in cancer. Given the short life times of the hyperpolarized signal, fast and effective spectroscopic imaging methods compatible with dynamic metabolic characterizations are necessary. Several approaches have been customized for hyperpolarized (13)C MRI, including CSI with a center-out k-space encoding, EPSI, and spectrally selective pulses in combination with spiral EPI acquisitions. Recent studies have described the potential of single-shot alternatives based on spatiotemporal encoding (SPEN) principles, to derive chemical-shift images within a sub-second period. By contrast to EPSI, SPEN does not require oscillating acquisition gradients to deliver chemical-shift information: its signal encodes both spatial as well as chemical shift information, at no extra cost in experimental complexity. SPEN MRI sequences with slice-selection and arbitrary excitation pulses can also be devised, endowing SPEN with the potential to deliver single-shot multi-slice chemical shift images, with a temporal resolution required for hyperpolarized dynamic metabolic imaging. The present work demonstrates this with initial in vivo results obtained from SPEN-based imaging of pyruvate and its metabolic products, after injection of hyperpolarized [1-(13)C]pyruvate. Multi-slice chemical-shift images of healthy rats were obtained at 4.7T in the region of the kidney, and 4D (2D spatial, 1D spectral, 1D temporal) data sets were obtained at 7T from a murine lymphoma tumor model.
Type:
Journal article
Language:
English
Published in:
Journal of Magnetic Resonance, 2014, Vol 240C, p. 8-15
Keywords:
Algorithms; Animals; Echo-Planar Imaging; Kidney; Lactic Acid; Lymphoma; Magnetic Resonance Imaging; Male; Mice; Neoplasms; Neoplasms, Experimental; Phantoms, Imaging; Pyruvic Acid; Rats; Rats, Sprague-Dawley; Signal-To-Noise Ratio; Journal Article; Research Support, Non-U.S. Gov't
Main Research Area:
Medical science
Publication Status:
Published
Review type:
Peer Review
Submission year:
2014
Scientific Level:
Scientific
ID:
260074651

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