- Authors:
-
- Dantoft, Thomas Meinertz ;
- Elberling, J. ;
-
Brix, Susanne
;
Close
0000-0001-8951-6705
Center for Biological Sequence Analysis, Department of Systems Biology, Technical University of Denmark - Szecsi, P.B. ;
- Vesterhauge, S. ;
- Skovbjerg, S.
- DOI:
- 10.1016/j.psyneuen.2013.11.012
- Abstract:
- BackgroundMultiple chemical sensitivity (MCS) is a medically unexplained condition characterized by reports of recurrent unspecific symptoms attributed to exposure to low levels of common volatile chemicals. The etiology of MCS is poorly understood, but dysregulation of the immune system has been proposed as part of the pathophysiology. ObjectiveTo compare plasma levels of cytokines in Danish MCS individuals with a healthy, sex- and age-matched control group. MethodBlood samples were obtained from 150 un-exposed MCS individuals and from 148 age- and sex-matched healthy controls. Plasma concentrations of 14 cytokines, chemokines and growth and allergen-specific IgE were measured. All participants completed a questionnaire including questions on MCS, psychological distress, morbidities and medication use at the time of the study. ResultsPlasma levels of interleukin-1β, -2, -4, and -6 were significantly (P
- Type:
- Journal article
- Language:
- English
- Published in:
- Psychoneuroendocrinology, 2014, Vol 40, p. 140-150
- Keywords:
- Multiple chemical sensitivity; Cytokines; Immunological regulation; Sickness behavior; Case–control studies; Journal Article; Research Support, Non-U.S. Gov't; Adolescent; Adult; Aged; Case-Control Studies; Comorbidity; Female; Humans; Inflammation; Inflammation Mediators; Male; Middle Aged; Multiple Chemical Sensitivity; Young Adult
- Main Research Area:
- Science/technology
- Publication Status:
- Published
- Review type:
- Peer Review
- Submission year:
- 2014
- Scientific Level:
- Scientific
- ID:
- 259822520
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