An, Ping5; Miljkovic, Iva6; Thyagarajan, Bharat7; Kraja, Aldi T5; Daw, E Warwick5; Pankow, James S7; Selvin, Elizabeth8; Kao, W H Linda8; Maruthur, Nisa M9; Nalls, Micahel A10; Liu, Yongmei11; Harris, Tamara B12; Lee, Joseph H13; Borecki, Ingrid B5; Christensen, Kaare15; Eckfeldt, John H7; Mayeux, Richard13; Perls, Thomas T14; Newman, Anne B6; Province, Michael A5
1 Epidemiology, Biostatistics and Biodemography, Department of Public Health, Det Sundhedsvidenskabelige Fakultet, SDU2 The Danish Twin Registry, Department of Public Health, Det Sundhedsvidenskabelige Fakultet, SDU3 Danish Aging Research Center, Department of Public Health, Det Sundhedsvidenskabelige Fakultet, SDU4 Human Genetics, Department of Clinical Research, Det Sundhedsvidenskabelige Fakultet, SDU5 Washington University6 University of Pittsburgh7 University of Minnesota8 Department of Epidemiology, Johns Hopkins University, Baltimore, MD, USA.9 Division of General Internal Medicine, Johns Hopkins University, Baltimore, MD, USA.10 Laboratory of Neurogenetics, NIA/NIH, Bethesda, MD, USA.11 Wake Forest University12 Laboratory of Epidemiology, Demography and Biometry, NIA/NIH, Bethesda, MD, USA.13 Gertrude H. Sergievsky Center and the Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University, New York City, NY, USA.14 Division of Geriatrics, Department of Medicine, Boston University Medical Center, Boston, MA, USA.15 Epidemiology, Biostatistics and Biodemography, Department of Public Health, Det Sundhedsvidenskabelige Fakultet, SDU
The Long Life Family Study (LLFS)
Glycated hemoglobin (HbA1c) is a stable index of chronic glycemic status and hyperglycemia associated with progressive development of insulin resistance and frank diabetes. It is also associated with premature aging and increased mortality. To uncover novel loci for HbA1c that are associated with healthy aging, we conducted a genome-wide association study (GWAS) using non-diabetic participants in the Long Life Family Study (LLFS), a study with familial clustering of exceptional longevity in the US and Denmark.
Metabolism, 2014, Vol 63, Issue 4, p. 461-8
ARIC; BMI; Body mass index; GWAS; Genome-wide association study; Glucose; Clycated hemoglobin; HABC; HbA1c; Insulin resistancy and diabetes; LLFS; Non-enzymatic glycation; Premature aging processes; The Atherosclerosis Risk in Communities Study; The Health, Aging, and Body Composition Study; The Long Life Family Study; Insulin resistance and diabetes