Glycated hemoglobin (HbA1c) is a stable index of chronic glycemic status and hyperglycemia associated with progressive development of insulin resistance and frank diabetes. It is also associated with premature aging and increased mortality. To uncover novel loci for HbA1c that are associated with healthy aging, we conducted a genome-wide association study (GWAS) using non-diabetic participants in the Long Life Family Study (LLFS), a study with familial clustering of exceptional longevity in the US and Denmark.
Metabolism, 2014, Vol 63, Issue 4, p. 461-8
ARIC; BMI; Body mass index; GWAS; Genome-wide association study; Glucose; Clycated hemoglobin; HABC; HbA1c; Insulin resistancy and diabetes; LLFS; Non-enzymatic glycation; Premature aging processes; The Atherosclerosis Risk in Communities Study; The Health, Aging, and Body Composition Study; The Long Life Family Study; Insulin resistance and diabetes