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Genome-wide association study identifies common loci influencing circulating glycated hemoglobin (HbA1c) levels in non-diabetic subjects

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Authors:
  • An, Ping ;
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    University of Washington
  • Miljkovic, Iva ;
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    University of Pittsburgh
  • Thyagarajan, Bharat ;
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    University of Minnesota
  • Kraja, Aldi T ;
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    University of Washington
  • Daw, E Warwick ;
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    University of Washington
  • Pankow, James S ;
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    University of Minnesota
  • Selvin, Elizabeth ;
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    Johns Hopkins University
  • Kao, W H Linda ;
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    Johns Hopkins University
  • Maruthur, Nisa M ;
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    Johns Hopkins University
  • Nalls, Micahel A ;
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    Laboratory of Neurogenetics, NIA/NIH, Bethesda, MD, USA.
  • Liu, Yongmei ;
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    Wake Forest University
  • Harris, Tamara B ;
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    Laboratory of Epidemiology, Demography and Biometry, NIA/NIH, Bethesda, MD, USA.
  • Lee, Joseph H ;
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    Columbia University
  • Borecki, Ingrid B ;
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    University of Washington
  • Christensen, Kaare ;
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    Orcid logo0000-0002-5429-5292
    Epidemiology, Biostatistics and Biodemography, Department of Public Health, Faculty of Health Sciences, SDU
  • Eckfeldt, John H ;
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    University of Minnesota
  • Mayeux, Richard ;
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    Columbia University
  • Perls, Thomas T ;
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    Boston Medical Center
  • Newman, Anne B ;
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    University of Pittsburgh
  • Province, Michael A
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    University of Washington
Subtitle:
The Long Life Family Study (LLFS)
DOI:
10.1016/j.metabol.2013.11.018
Abstract:
Glycated hemoglobin (HbA1c) is a stable index of chronic glycemic status and hyperglycemia associated with progressive development of insulin resistance and frank diabetes. It is also associated with premature aging and increased mortality. To uncover novel loci for HbA1c that are associated with healthy aging, we conducted a genome-wide association study (GWAS) using non-diabetic participants in the Long Life Family Study (LLFS), a study with familial clustering of exceptional longevity in the US and Denmark.
Type:
Journal article
Language:
English
Published in:
Metabolism, 2014, Vol 63, Issue 4, p. 461-8
Keywords:
ARIC; BMI; Body mass index; GWAS; Genome-wide association study; Glucose; Clycated hemoglobin; HABC; HbA1c; Insulin resistancy and diabetes; LLFS; Non-enzymatic glycation; Premature aging processes; The Atherosclerosis Risk in Communities Study; The Health, Aging, and Body Composition Study; The Long Life Family Study; Insulin resistance and diabetes
Main Research Area:
Medical science
Publication Status:
Published
Review type:
Peer Review
Submission year:
2014
Scientific Level:
Scientific
ID:
259767798

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