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Derived immune and ancestral pigmentation alleles in a 7,000-year-old Mesolithic European

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Authors:
  • Olalde, Inigo ;
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    Institut de Biologia Evolutiva
  • Allentoft, Morten E. ;
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    University of Copenhagen
  • Sanchez-Quinto, Federico ;
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    Institut de Biologia Evolutiva
  • Santpere, Gabriel ;
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    Institut de Biologia Evolutiva
  • Chiang, Charleston W. K. ;
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    University of California
  • DeGiorgio, Michael ;
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    University of California at Berkeley
  • Prado-Martinez, Javier ;
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    Institut de Biologia Evolutiva
  • Rodriguez, Juan Antonio ;
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    Institut de Biologia Evolutiva
  • Rasmussen, Simon ;
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    Orcid logo0000-0001-6323-9041
    Center for Biological Sequence Analysis, Department of Systems Biology, Technical University of Denmark
  • Quilez, Javier ;
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    Institut de Biologia Evolutiva
  • Ramirez, Oscar ;
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    Institut de Biologia Evolutiva
  • Marigorta, Urko M. ;
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    Institut de Biologia Evolutiva
  • Fernandez-Callejo, Marcos ;
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    Institut de Biologia Evolutiva
  • Prada, Maria Encina ;
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    I.E.S.O. 'Los Salados'
  • Encinas, Julio Manuel Vidal ;
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    Junta de Castilla y León
  • Nielsen, Rasmus ;
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    University of California at Berkeley
  • Netea, Mihai G. ;
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    Radboud University Nijmegen
  • Novembre, John ;
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    University of Chicago
  • Sturm, Richard A. ;
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    University of Queensland
  • Sabeti, Pardis ;
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    Harvard University
  • Marques-Bonet, Tomas ;
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    Catalan Institution for Research and Advanced Studies
  • Navarro, Arcadi ;
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    Catalan Institution for Research and Advanced Studies
  • Willerslev, Eske ;
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    University of Copenhagen
  • Lalueza-Fox, Carles
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    Institut de Biologia Evolutiva
DOI:
10.1038/nature12960
Abstract:
Ancient genomic sequences have started to reveal the origin and the demographic impact of farmers from the Neolithic period spreading into Europe(1-3). The adoption of farming, stock breeding and sedentary societies during the Neolithic may have resulted in adaptive changes in genes associated with immunity and diet(4). However, the limited data available from earlier hunter-gatherers preclude an understanding of the selective processes associated with this crucial transition to agriculture in recent human evolution. Here we sequence an approximately 7,000-year-old Mesolithic skeleton discovered at the La Brana-Arintero site in Leon, Spain, to retrieve a complete pre-agricultural European human genome. Analysis of this genome in the context of other ancient samples suggests the existence of a common ancient genomic signature across western and central Eurasia from the Upper Paleolithic to the Mesolithic. The La Brana individual carries ancestral alleles in several skin pigmentation genes, suggesting that the light skin of modern Europeans was not yet ubiquitous in Mesolithic times. Moreover, we provide evidence that a significant number of derived, putatively adaptive variants associated with pathogen resistance in modern Europeans were already present in this hunter-gatherer.
Type:
Journal article
Language:
English
Published in:
Nature, 2014, Vol 507, Issue 7491, p. 225-228
Keywords:
Evolutionary genetics
Main Research Area:
Science/technology
Publication Status:
Published
Review type:
Peer Review
Submission year:
2014
Scientific Level:
Scientific
ID:
259643568

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