Kaur-Knudsen, Diljit3; Zachariae, Claus1; Thomsen, Simon Francis2
1 Dermatology and Allergy, Herlev and Gentofte Hospital, The Capital Region of Denmark2 Dermato-Venerologisk Afdeling og Videncenter for Sårheling (D/S), Bispebjerg and Frederiksberg Hospital, The Capital Region of Denmark3 Clinical Biochemistry, Herlev and Gentofte Hospital, The Capital Region of Denmark
Stevens-Johnson syndrome and toxic epidermal necrolysis are acute mucocutaneous diseases primarily due to drug intake. The diseases are characterised by the separation of epidermis from dermis which can be life-threatening. Mortality is often caused by sepsis and multiple organ failure. The most common drugs involved are antibiotics, antiepileptic medicine, allopurinol and nonsteroidal anti-inflammatory drugs. Besides withdrawing the suspected drug the treatment is mainly symptomatic. A number of systemic treatments have been suggested including systemic corticosteroids, intravenous immunoglobulins, cyclosporine, granulocyte colony stimulating factor and tumour necrosis factor-alpha inhibitors although they remain controversial.
Ugeskrift for Laeger, 2013, Vol 175, Issue 50, p. 3096-9