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Self-reactive T cells

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Authors:
  • Becker, Jürgen C ;
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    University of Graz
  • thor Straten, Per ;
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    Orcid logo0000-0002-4731-4969
    Haematology, Department of, Herlev and Gentofte Hospital, The Capital Region of Denmark
  • Andersen, Mads Hald
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    Haematology, Department of, Herlev and Gentofte Hospital, The Capital Region of Denmark
Subtitle:
suppressing the suppressors
DOI:
10.1007/s00262-013-1512-9
Abstract:
The immune system is a tightly regulated and complex system. An important part of this immune regulation is the assurance of tolerance toward self-antigens to maintain immune homeostasis. However, in recent years, antigen-specific cellular immune responses toward several normal self-proteins expressed in regulatory immune cells have been reported, especially in patients with cancer. The seemingly lack of tolerance toward such proteins is interesting, as it suggests a regulatory function of self-reactive T (srT) cells, which may be important for the fine tuning of the immune system. In particular, surprising has been the description of cytotoxic srT cells that are able to eliminate normal regulatory immune cells. Such srT cells may be important as effector cells that suppress regulatory suppressor cells. The current knowledge of the nature and function of srT cells is still limited. Still, the therapeutic targeting of srT cells offers a novel approach to harness immune-regulatory networks in cancer.
Type:
Journal article
Language:
English
Published in:
Cancer Immunology, Immunotherapy : Cii, 2014, Vol 63, Issue 4, p. 313-319
Keywords:
Journal Article; Research Support, Non-U.S. Gov't; Review
Main Research Area:
Medical science
Publication Status:
Published
Review type:
Peer Review
Submission year:
2014
Scientific Level:
Scientific
ID:
258767274

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