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Soluble TNF-Alpha-Receptors I Are Prognostic Markers in TIPS-Treated Patients with Cirrhosis and Portal Hypertension

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Authors:
  • Trebicka, Jonel ;
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    unknown
  • Krag, Aleksander ;
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    Department of Clinical Medicine, Faculty of Health and Medical Sciences, Københavns Universitet
  • Gansweid, Stefan ;
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    unknown
  • Schiedermaier, Peter ;
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    unknown
  • Strunk, Holger M ;
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    unknown
  • Fimmers, Rolf ;
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    unknown
  • Strassburg, Christian P ;
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    unknown
  • Bendtsen, Flemming ;
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    Department of Clinical Medicine, Department of Clinical Medicine, Faculty of Health and Medical Sciences, Københavns Universitet
  • Møller, Søren ;
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    Section of Diagnostic Sciences, Department of Clinical Medicine, Faculty of Health and Medical Sciences, Københavns Universitet
  • Sauerbruch, Tilman ;
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    unknown
  • Spengler, Ulrich
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    unknown
DOI:
10.1371/journal.pone.0083341
Abstract:
TNFα levels are increased in liver cirrhosis even in the absence of infection, most likely owing to a continuous endotoxin influx into the portal blood. Soluble TNFα receptors (sTNFR type I and II) reflect release of the short-lived TNFα, because they are cleaved from the cells after binding of TNFα. The aims were to investigate the circulating levels of soluble TNFR-I and -II in cirrhotic patients receiving TIPS.
Type:
Journal article
Language:
English
Published in:
P L O S One, 2013, Vol 8, Issue 12
Keywords:
Journal Article; Research Support, Non-U.S. Gov't
Main Research Area:
Medical science
Publication Status:
Published
Review type:
Peer Review
Submission year:
2013
Scientific Level:
Scientific
ID:
258726584

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