Friis-Ottessen, Mariann4; Bendix, Laila6; Kølvraa, Steen7; Norheim-Andersen, Solveig4; De Angelis, Paula M4; Clausen, Ole Petter4
1 Danish Aging Research Center, Department of Public Health, Det Sundhedsvidenskabelige Fakultet, SDU2 Epidemiology, Biostatistics and Biodemography, Department of Public Health, Det Sundhedsvidenskabelige Fakultet, SDU3 Department of Genetics, Institute of Regional Health Research, Det Sundhedsvidenskabelige Fakultet, SDU4 unknown5 Det Sundhedsvidenskabelige Fakultet, SDU6 Danish Aging Research Center, Department of Public Health, Det Sundhedsvidenskabelige Fakultet, SDU7 Det Sundhedsvidenskabelige Fakultet, SDU
Ulcerative colitis (UC) is a chronic, inflammatory bowel disease which may lead to dysplasia and adenocarcinoma in patients when long-lasting. Short telomeres have been reported in mucosal cells of UC patients. Telomeres are repetitive base sequences capping the ends of linear chromosomes, and protect them from erosion and subsequent wrongful recombination and end-to-end joining during cell division. Short telomeres are associated with the development of chromosomal instability and aneuploidy, the latter being risk factors for development of dysplasia and cancer. Specifically, the abrupt shortening of one or more telomeres to a critical length, rather than bulk shortening of telomeres, seems to be associated with chromosomal instability.