Leukocyte telomere length (LTL) ostensibly shortens with age and has been moderately associated with mortality. In humans, these findings have come almost solely from cross-sectional studies. Only recently has LTL shortening within individuals been analyzed in longitudinal studies. Such studies are relevant to establish LTL dynamics as biomarkers of mortality as well as to disentangle the causality of telomeres on aging.
Journals of Gerontology. Series A, Biological Sciences and Medical Sciences, 2014, Vol 69, Issue 2, p. 231-9
Journal Article; Research Support, Non-U.S. Gov't; Biomarkers; Longevity; DNA damage and repair; Epidemiology