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Microbial enterotypes, inferred by the prevotella-to-bacteroides ratio, remained stable during a 6-month randomized controlled diet intervention with the new nordic diet

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Authors:
  • Roager, Henrik Munch ;
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    Orcid logo0000-0002-2504-8313
    National Food Institute, Technical University of Denmark
  • Licht, Tine Rask ;
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    Orcid logo0000-0002-6399-9574
    National Food Institute, Technical University of Denmark
  • Poulsen, Sanne ;
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    University of Copenhagen
  • Larsen, Thomas Meinert ;
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    University of Copenhagen
  • Bahl, Martin Iain
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    Orcid logo0000-0003-1579-8038
    National Food Institute, Technical University of Denmark
DOI:
10.1128/AEM.03549-13
Abstract:
It has been suggested that the human gut microbiota can be divided into enterotypes based on the abundance of specific bacterial groups; however, the biological significance and stability of these enterotypes remain unresolved. Here, we demonstrated that subjects (n = 62) 18 to 65 years old with central obesity and components of metabolic syndrome could be grouped into two discrete groups simply by their relative abundance of Prevotella spp. divided by Bacteroides spp. (P/B ratio) obtained by quantitative PCR analysis. Furthermore, we showed that these groups remained stable during a 6-month, controlled dietary intervention, where the effect of consuming a diet in accord with the new Nordic diet (NND) recommendations as opposed to consuming the average Danish diet (ADD) on the gut microbiota was investigated. In this study, subjects (with and without stratification according to P/B ratio) did not reveal significant changes in 35 selected bacterial taxa quantified by quantitative PCR (ADD compared to NND) resulting from the dietary interventions. However, we found higher total plasma cholesterol within the high-P/B group than in the low-P/B group after the intervention. We propose that stratification of humans based simply on their P/B ratio could allow better assessment of possible effects of interventions on the gut microbiota and physiological biomarkers.
Type:
Journal article
Language:
English
Published in:
Applied and Environmental Microbiology, 2014, Vol 80, Issue 3, p. 1142-1149
Keywords:
Bacteroides; Cholesterol; Diet; Feces; Gastrointestinal Tract; Humans; Metagenome; Plasma; Prevotella; Real-Time Polymerase Chain Reaction
Main Research Area:
Science/technology
Publication Status:
Published
Review type:
Peer Review
Submission year:
2015
Scientific Level:
Scientific
ID:
258636732

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