BACKGROUND: Vitamin D, certain single nucleotide polymorphisms (SNPs) in the vitamin D-receptor (VDR) gene and vitamin D metabolism genes have been associated with type 1 diabetes (T1D). OBJECTIVE: We wanted to examine if the most widely studied SNPs in genes important for production, transport, and action of vitamin D were associated with T1D or to circulating levels of vitamin D 25-hydroxyvitamin D [25(OH)D] in a juvenile Danish population. METHODS: We genotyped eight SNPs in five vitamin D metabolism genes in 1467 trios. 25(OH)D status were analyzed in 1803 children (907 patients and 896 siblings). RESULTS: We did not demonstrate association with T1D for SNPs in the following genes: CYP27B1, VDR, GC, CYP2R1, DHCR7, and CYP24A1. Though, variants in the GC gene were significantly associated with 25(OH)D levels in the joint model. CONCLUSION: Some of the most examined SNPs in vitamin D metabolism genes were not confirmed to be associated with T1D, though 25(OH) levels were associated with variants in the GC gene.
Pediatric Diabetes, 2014, Vol 15, Issue 6, p. 416-421
25-Hydroxyvitamin D3 1-alpha-Hydroxylase; Adolescent; Child; Child, Preschool; Cholestanetriol 26-Monooxygenase; Denmark; Diabetes Mellitus, Type 1; Female; Genetic Association Studies; Genetic Predisposition to Disease; Humans; Infant; Infant, Newborn; Male; Metabolic Networks and Pathways; Oxidoreductases Acting on CH-CH Group Donors; Polymorphism, Single Nucleotide; Receptors, Calcitriol; Vitamin D; Vitamin D-Binding Protein; Vitamin D3 24-Hydroxylase; Journal Article