Sueiras, M1; Sahuquillo, J1; García-López, B1; Sánchez-Guerrero, Á1; Poca, M A1; Santamarina, E1; Riveiro, M1; Fabricius, M2; Strong, A J1
1 unknown2 Klinisk Neurofysiologisk Klinik, Neurocentret, Rigshospitalet, The Capital Region of Denmark
OBJECTIVES: To determine the frequency and duration of cortical spreading depolarization (CSD) and CSD-like episodes in patients with traumatic brain injury (TBI) and malignant middle cerebral artery infarction (MMCAI) requiring craniotomy. DESIGN: A descriptive observational study was carried out during 19 months. SETTING: Neurocritical patients. PATIENTS: Sixteen patients were included: 9 with MMCAI and 7 with moderate or severe TBI, requiring surgical treatment. INTERVENTIONS: A 6-electrode subdural electrocorticographic (ECoG) strip was placed onto the perilesional cortex. MAIN VARIABLES OF INTEREST: An analysis was made of the time profile and the number and duration of CSD and CSD-like episodes recorded from the ECoGs. RESULTS: Of the 16 patients enrolled, 9 presented episodes of CSD or CSD-like phenomena, of highly variable frequency and duration. CONCLUSIONS: Episodes of CSD and CSD-like phenomena are frequently detected in the ischemic penumbra and/or traumatic cortical regions of patients with MMCAI who require decompressive craniectomy or of patients with contusional TBI.
Medicina Intensiva / Sociedad Española De Medicina Intensiva Y Unidades Coronarias, 2014, Vol 38, Issue 7, p. 413-21