1 Department of Biomedicine - Forskning og uddannelse, Øst, Department of Biomedicine, Health, Aarhus University2 Department of Biomedicine - Department of Human Genetics, Department of Biomedicine, Health, Aarhus University3 unknown4 Ditzel-gruppen5 2012 Faggruppe Patobiologi6 Department of Biomedicine - Forskning og uddannelse, Øst, Department of Biomedicine, Health, Aarhus University
Development of resistance to tamoxifen is an important clinical issue in the treatment of breast cancer. Tamoxifen resistance may be the result of acquisition of epigenetic regulation within breast cancer cells, such as DNA methylation, resulting in changed mRNA expression of genes pivotal for estrogen-dependent growth. Alternatively, tamoxifen resistance may be due to selection of pre-existing resistant cells, or a combination of the two mechanisms.
Breast Cancer Research (online Edition), 2013, Vol 15, Issue 6