1 Molecular Disease Biology, Department of Veterinary Disease Biology, Faculty of Health and Medical Sciences, Københavns Universitet2 Institut for Biomedicin - Forskning og uddannelse, Øst3 Institut for Biomedicin - Human Genetik4 Sino-Danish Breast Cancer Research Centre5 Tongji University6 Institut for Klinisk Medicin - Eksperimentiel Klinisk Onkologi Afdeling F, NBG7 Tongji University8 Molecular Disease Biology, Department of Veterinary Disease Biology, Faculty of Health and Medical Sciences, Københavns Universitet
Development of resistance to tamoxifen is an important clinical issue in the treatment of breast cancer. Tamoxifen resistance may be the result of acquisition of epigenetic regulation within breast cancer cells, such as DNA methylation, resulting in changed mRNA expression of genes pivotal for estrogen-dependent growth. Alternatively, tamoxifen resistance may be due to selection of pre-existing resistant cells, or a combination of the two mechanisms.
Breast Cancer Research : Bcr, 2013, Vol 15, Issue 6