Chu, Brian K.2; Deming, Michael3; Biritwum, Nana-Kwadwo4; Bougma, Windtaré R.5; Dorkenoo, Améyo M.6; El-Setouhy, Maged7; Fischer, Peter U.8; Gass, Katherine2; Peña, Manuel Gonzalez de9; Simonsen, Paul Erik10
1 Parasitology and Aquatic Diseases, Department of Veterinary Disease Biology, Faculty of Health and Medical Sciences, Københavns Universitet2 Task Force for Global Health3 Centers for Disease Control and Prevention4 Ghana Health Service5 Ministère de la Santé6 Ministère de la Santé7 Ain Shams University8 Washington University School of Medicine9 Centro National de Control de Enfermedades Tropicales10 Parasitology and Aquatic Diseases, Department of Veterinary Disease Biology, Faculty of Health and Medical Sciences, Københavns Universitet
a multicenter evaluation
Lymphatic filariasis (LF) is targeted for global elimination through treatment of entire at-risk populations with repeated annual mass drug administration (MDA). Essential for program success is defining and confirming the appropriate endpoint for MDA when transmission is presumed to have reached a level low enough that it cannot be sustained even in the absence of drug intervention. Guidelines advanced by WHO call for a transmission assessment survey (TAS) to determine if MDA can be stopped within an LF evaluation unit (EU) after at least five effective rounds of annual treatment. To test the value and practicality of these guidelines, a multicenter operational research trial was undertaken in 11 countries covering various geographic and epidemiological settings.
P L O S Neglected Tropical Diseases (online), 2013, Vol 7, Issue 12