1 Computational and RNA Biology, Department of Biology, Faculty of Science, Københavns Universitet2 Department of Biology, Faculty of Science, Københavns Universitet3 University of British Columbia4 Université Grenoble-Alpes5 unknown6 University of British Columbia7 Computational and RNA Biology, Department of Biology, Faculty of Science, Københavns Universitet8 Department of Biology, Faculty of Science, Københavns Universitet
an extensively expanded and updated open-access database of transcription factor binding profiles
JASPAR (http://jaspar.genereg.net) is the largest open-access database of matrix-based nucleotide profiles describing the binding preference of transcription factors from multiple species. The fifth major release greatly expands the heart of JASPAR-the JASPAR CORE subcollection, which contains curated, non-redundant profiles-with 135 new curated profiles (74 in vertebrates, 8 in Drosophila melanogaster, 10 in Caenorhabditis elegans and 43 in Arabidopsis thaliana; a 30% increase in total) and 43 older updated profiles (36 in vertebrates, 3 in D. melanogaster and 4 in A. thaliana; a 9% update in total). The new and updated profiles are mainly derived from published chromatin immunoprecipitation-seq experimental datasets. In addition, the web interface has been enhanced with advanced capabilities in browsing, searching and subsetting. Finally, the new JASPAR release is accompanied by a new BioPython package, a new R tool package and a new R/Bioconductor data package to facilitate access for both manual and automated methods.