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The identification of AF38469: An orally bioavailable inhibitor of the VPS10P family sorting receptor Sortilin

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Authors:
  • Schrøder, Tenna Juul ;
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    Neuroscience Drug Discovery, H. Lundbeck A/S, Copenhagen, Denmark.
  • Christensen, Søren ;
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    Neuroscience Drug Discovery, H. Lundbeck A/S, Copenhagen, Denmark.
  • Lindberg, Samsa ;
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    Neuroscience Drug Discovery, H. Lundbeck A/S, Copenhagen, Denmark.
  • Langgård, Morten ;
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    Neuroscience Drug Discovery, H. Lundbeck A/S, Copenhagen, Denmark.
  • David, Laurent ;
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    Neuroscience Drug Discovery, H. Lundbeck A/S, Copenhagen, Denmark.
  • Maltas, Philip J ;
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    Neuroscience Drug Discovery, H. Lundbeck A/S, Copenhagen, Denmark.
  • Eskildsen, Jørgen ;
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    Risø National Laboratory for Sustainable Energy
  • Jacobsen, Jan ;
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    Neuroscience Drug Discovery, H. Lundbeck A/S, Copenhagen, Denmark.
  • Tagmose, Lena ;
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    Neuroscience Drug Discovery, H. Lundbeck A/S, Copenhagen, Denmark.
  • Simonsen, Klaus Bæk ;
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    Neuroscience Drug Discovery, H. Lundbeck A/S, Copenhagen, Denmark.
  • Biilmann Rønn, Lars Christian ;
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    Neuroscience Drug Discovery, H. Lundbeck A/S, Copenhagen, Denmark.
  • de Jong, Inge Elisabeth Maria ;
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    2012 Institut for Farmakologi og Farmakoterapi
  • Malik, Ibrahim J ;
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    Neuroscience Drug Discovery, H. Lundbeck A/S, Copenhagen, Denmark.
  • Karlsson, Jens-Jakob ;
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    Department of Chemistry
  • Bundgaard, Christoffer ;
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    2012 Institut for Farmakologi og Farmakoterapi
  • Egebjerg, Jan ;
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    Neuroscience Drug Discovery, H. Lundbeck A/S, Copenhagen, Denmark.
  • Stavenhagen, Jeffrey B ;
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    Neuroscience Drug Discovery, H. Lundbeck A/S, Copenhagen, Denmark.
  • Strandbygård, Dorthe ;
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    Department of Molecular Biology and Genetics - Structural Biology, Department of Molecular Biology and Genetics, Science and Technology, Aarhus University
  • Thirup, Søren Skou ;
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    Department of Molecular Biology and Genetics - Structural Biology, Department of Molecular Biology and Genetics, Science and Technology, Aarhus University
  • Andersen, Jacob Lauwring ;
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    Department of Molecular Biology and Genetics - DANDRITE, Department of Molecular Biology and Genetics, Science and Technology, Aarhus University
  • Uppalanchi, Srinivas ;
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    Medicinal Chemistry, GVK BioScience, Hyderabad, India.
  • Pervaram, Sridhar ;
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    Medicinal Chemistry, GVK BioScience, Hyderabad, India.
  • Kasturi, Shiva Prasad ;
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    Medicinal Chemistry, GVK BioScience, Hyderabad, India.
  • Eradi, Pradheep ;
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    Medicinal Chemistry, GVK BioScience, Hyderabad, India.
  • Sakumudi, Durga Rao ;
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    Medicinal Chemistry, GVK BioScience, Hyderabad, India.
  • Watson, Stephen Paul
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    2012 Institut for Farmakologi og Farmakoterapi
Subtitle:
An orally bioavailable inhibitor of the VPS10P family sorting receptor Sortilin
DOI:
10.1016/j.bmcl.2013.11.046
Type:
Journal article
Language:
English
Published in:
Bioorganic and Medicinal Chemistry Letters, 2014, Vol 24, Issue 1, p. 177-180
Main Research Area:
Science/technology
Publication Status:
Published
Review type:
Peer Review
Submission year:
2014
Scientific Level:
Scientific
ID:
256710434

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