The identification of AF38469: An orally bioavailable inhibitor of the VPS10P family sorting receptor Sortilin

Tenna Juul Schrøder; Søren Christensen; Samsa Lindberg; Morten Langgård; Laurent David; Philip J Maltas; Jørgen Eskildsen; Jan Jacobsen; Lena Tagmose; Klaus Bæk Simonsen; Lars Christian Biilmann Rønn; Inge Elisabeth Maria de Jong; Ibrahim J Malik; Jens-Jakob Karlsson; Christoffer Bundgaard; Jan Egebjerg; Jeffrey B Stavenhagen; Dorthe Strandbygård; Søren Skou Thirup; Jacob Lauwring Andersen; Srinivas Uppalanchi; Sridhar Pervaram; Shiva Prasad Kasturi; Pradheep Eradi; Durga Rao Sakumudi; Stephen Paul Watson

doi:10.1016/j.bmcl.2013.11.046

The identification of AF38469: An orally bioavailable inhibitor of the VPS10P family sorting receptor Sortilin

Authors:

Schrøder, Tenna Juul ;
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Neuroscience Drug Discovery, H. Lundbeck A/S, Copenhagen, Denmark.
Christensen, Søren ;
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Neuroscience Drug Discovery, H. Lundbeck A/S, Copenhagen, Denmark.
Lindberg, Samsa ;
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Neuroscience Drug Discovery, H. Lundbeck A/S, Copenhagen, Denmark.
Langgård, Morten ;
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Neuroscience Drug Discovery, H. Lundbeck A/S, Copenhagen, Denmark.
David, Laurent ;
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Neuroscience Drug Discovery, H. Lundbeck A/S, Copenhagen, Denmark.
Maltas, Philip J ;
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Neuroscience Drug Discovery, H. Lundbeck A/S, Copenhagen, Denmark.
Eskildsen, Jørgen ;
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Risø National Laboratory for Sustainable Energy
Jacobsen, Jan ;
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Neuroscience Drug Discovery, H. Lundbeck A/S, Copenhagen, Denmark.
Tagmose, Lena ;
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Neuroscience Drug Discovery, H. Lundbeck A/S, Copenhagen, Denmark.
Simonsen, Klaus Bæk ;
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Neuroscience Drug Discovery, H. Lundbeck A/S, Copenhagen, Denmark.
Biilmann Rønn, Lars Christian ;
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Neuroscience Drug Discovery, H. Lundbeck A/S, Copenhagen, Denmark.
de Jong, Inge Elisabeth Maria ;
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2012 Institut for Farmakologi og Farmakoterapi
Malik, Ibrahim J ;
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Neuroscience Drug Discovery, H. Lundbeck A/S, Copenhagen, Denmark.
Karlsson, Jens-Jakob ;
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Department of Chemistry
Bundgaard, Christoffer ;
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2012 Institut for Farmakologi og Farmakoterapi
Egebjerg, Jan ;
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Neuroscience Drug Discovery, H. Lundbeck A/S, Copenhagen, Denmark.
Stavenhagen, Jeffrey B ;
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Neuroscience Drug Discovery, H. Lundbeck A/S, Copenhagen, Denmark.
Strandbygård, Dorthe ;
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Department of Molecular Biology and Genetics - Structural Biology, Department of Molecular Biology and Genetics, Science and Technology, Aarhus University
Thirup, Søren Skou ;
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Department of Molecular Biology and Genetics - Structural Biology, Department of Molecular Biology and Genetics, Science and Technology, Aarhus University
Andersen, Jacob Lauwring ;
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Department of Molecular Biology and Genetics - DANDRITE, Department of Molecular Biology and Genetics, Science and Technology, Aarhus University
Uppalanchi, Srinivas ;
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Medicinal Chemistry, GVK BioScience, Hyderabad, India.
Pervaram, Sridhar ;
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Medicinal Chemistry, GVK BioScience, Hyderabad, India.
Kasturi, Shiva Prasad ;
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Medicinal Chemistry, GVK BioScience, Hyderabad, India.
Eradi, Pradheep ;
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Medicinal Chemistry, GVK BioScience, Hyderabad, India.
Sakumudi, Durga Rao ;
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Medicinal Chemistry, GVK BioScience, Hyderabad, India.
Watson, Stephen Paul
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2012 Institut for Farmakologi og Farmakoterapi

Subtitle:

An orally bioavailable inhibitor of the VPS10P family sorting receptor Sortilin

DOI:

10.1016/j.bmcl.2013.11.046

Type:

Journal article

Language:

English

Published in:

Bioorganic and Medicinal Chemistry Letters, 2014, Vol 24, Issue 1, p. 177-180

Main Research Area:

Science/technology

Publication Status:

Published

Review type:

Peer Review

Submission year:

2014

Scientific Level:

Scientific

ID:

256710434

The identification of AF38469: An orally bioavailable inhibitor of the VPS10P family sorting receptor Sortilin

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