1 Department of Chemical and Biochemical Engineering, Technical University of Denmark2 Center for Process Engineering and Technology, Department of Chemical and Biochemical Engineering, Technical University of Denmark3 Department of Chemistry, Technical University of Denmark
Organic synthesis (incorporating both chemo-catalysis and biocatalysis) is essential for the production of a wide range of small-molecule pharmaceuticals. However, traditional production processes are mainly based on batch and semi-batch operating modes, which have disadvantages from an economic, environmental and manufacturing perspective. A potential solution to resolve these issues is to use flow chemistry in such processes, preferably with applications of micro-and mini-sized equipment. In addition, Process Analytical Technology (PAT) may be implemented in a very efficient way in such equipment due to the high degree of automation and process controllability that can be achieved in small scale continuous equipment.