Skov, Kasper4; Hadrup, Niels1; Vestergaard, Anne Marie5; Smedsgaard, Jørn1; Frandsen, Henrik Lauritz1
1 National Food Institute, Technical University of Denmark2 Division of Food Chemistry, National Food Institute, Technical University of Denmark3 Division of Toxicology and Risk Assessment, National Food Institute, Technical University of Denmark4 Department of Systems Biology, Technical University of Denmark5 Technical University of Denmark
Endocrine disrupting chemicals are compounds which interfere with normal hormone homeostasis. So far the main concern has been the effect on the reproduction and development. This study has been conducted to find the effect of EDC on the human metabolome, using LC high resolution mass spectrometry and chemical separation of plasma metabolites it is possible to find the difference in the plasma metabolome affected by EDC. The study was conducted given a group of rats an EDC and another group a combination of EDC’s and CYP inhibitors.
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9th International Conference of the Metabolomics Society, 2013