Lauritsen, Klara Tølbøll1; Nielsen, Elisabeth Okholm4; Christensen, Dennis5; Jungersen, Gregers1
1 National Veterinary Institute, Technical University of Denmark2 Section for Public sector service and commercial diagnostics, National Veterinary Institute, Technical University of Denmark3 Section for Immunology and Vaccinology, National Veterinary Institute, Technical University of Denmark4 Danish Agriculture and Food Council5 Statens Serum Institut
Infection with Mycoplasma hyosynoviae (M. hyosynoviae) is a known cause of arthritis and lameness in finishing pigs. Although antibiotic therapy will cure many cases, other ways of preventing M. hyosynoviae arthritis are warranted. The National Veterinary Institute has recently developed a M. hyosynoviae vaccine formulated with formalin-fixed whole-cell M. hyosynoviae and CAF01 (Statens Serum Institut, Denmark) as an adjuvant. This vaccine has recently shown promising results in experimentally infected pigs with development of both humoral and cell-mediated immune responses. The objective was to test this novel vaccine in a field trial in one Danish herd with recurrent arthritis problems due to infection with M. hyosynoviae. A total of 399 weaner pigs were included in a clinical trial. The pigs were vaccinated twice, two and five weeks after weaning. Half of the pigs were vaccinated with the novel M. hyosynoviae vaccine, and the other half were placebo injected (adjuvant + buffered saline). Two ml doses of both were injected intramuscularly in the neck. Vaccinated pigs and placebo pigs were mixed in the pens. There were no cases of lameness until the pigs were moved to the finishing unit at a bodyweight of 30 kg. In the finishing unit, arthritis due to infection with M. hyosynoviae was diagnosed by culture before and during the vaccine trial. Lameness was recorded in 23% of the vaccinated pigs and in 28% of the placebo pigs. The data were analysed by logistic regression, and no significant difference in the prevalence of lameness was found (P=0.157). All lame finishers were treated with Lincosin® and Flunixin® by injection for three days. In conclusion, this novel M. hyosynoviae vaccine could not successfully prevent the development of lameness in finishing pigs presumed to have been caused by M. hyosynoviae arthritis.
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5th European Symposium of Porcine Health Management (ESPHM 2012)