1 Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark2 New Bioactive Compounds, Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark3 Network Reconstruction in Silico Biology, Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark4 Korea Advanced Institute of Science & Technology
Streptomyces species continue to attract attention as a source of novel medicinal compounds. Despite a long history of studies on these microorganisms, they still have many biochemical mysteries to be elucidated. Investigations of novel secondary metabolites and their biosynthetic gene clusters have been more systematized with high-throughput techniques through inspections of correlations among components of the primary and secondary metabolisms at the genome scale. Moreover, up-to-date information on the genome of Streptomyces species with emphasis on their secondary metabolism has been collected in the form of databases and knowledgebases, providing predictive information and enabling one to explore experimentally unrecognized biological spaces of secondary metabolism. Herein, we review recent trends in the systems biology and biotechnology of Streptomyces species.
Biotechnology Advances, 2014, Vol 32, Issue 2, p. 255-268
Streptomyces species; Secondary metabolites; Systems biology; Systems biotechnology; Systems metabolic engineering; Omics techniques; Databases; Knowledgebases; Constraint-based flux analysis