Krysiak-Baltyn, Konrad1; Petersen, Thomas Nordahl1; Audouze, Karine Marie Laure2; Jørgensen, Niels3; Ängquist, L.3; Brunak, Søren1
1 Department of Systems Biology, Technical University of Denmark2 Center for Biological Sequence Analysis, Department of Systems Biology, Technical University of Denmark3 Copenhagen University Hospital
A hybrid method for clinical and biobank data mining
We describe a new method for identification of confident associations within large clinical data sets. The method is a hybrid of two existing methods; Self-Organizing Maps and Association Mining. We utilize Self-Organizing Maps as the initial step to reduce the search space, and then apply Association Mining in order to find association rules. We demonstrate that this procedure has a number of advantages compared to traditional Association Mining; it allows for handling numerical variables without a priori binning and is able to generate variable groups which act as “hotspots” for statistically significant associations. We showcase the method on infertility-related data from Danish military conscripts. The clinical data we analyzed contained both categorical type questionnaire data and continuous variables generated from biological measurements, including missing values. From this data set, we successfully generated a number of interesting association rules, which relate an observation with a specific consequence and the p-value for that finding. Additionally, we demonstrate that the method can be used on non-clinical data containing chemical–disease associations in order to find associations between different phenotypes, such as prostate cancer and breast cancer.
Journal of Biomedical Informatics, 2014, Vol 47, p. 160-170
Journal Article; Research Support, Non-U.S. Gov't; Data mining; Clinical data; Rule extraction; Self-Organizing Map; Association mining