Haibe-Kains, Benjamin3; El-Hachem, Nehme3; Birkbak, Nicolai Juul4; Jin, Andrew C.5; Beck, Andrew H5; Aerts, Hugo J. W. L.7; Quackenbush, John7
1 Department of Systems Biology, Technical University of Denmark2 Center for Biological Sequence Analysis, Department of Systems Biology, Technical University of Denmark3 University of Montreal4 Cancer Systems Biology, Center for Biological Sequence Analysis, Department of Systems Biology, Technical University of Denmark5 Harvard Medical School6 Dana-Farber Cancer Institute7 Dana-Farber Cancer Institute
Two large-scale pharmacogenomic studies were published recently in this journal. Genomic data are well correlated between studies; however, the measured drug response data are highly discordant. Although the source of inconsistencies remains uncertain, it has potential implications for using these outcome measures to assess gene-drug associations or select potential anticancer drugs on the basis of their reported results.