Frydland, Martin10; Kousholt, Birgitte S.10; Larsen, Jens Rolighed11; Burnett, John C.7; Hilsted, Linda8; Hasenkam, J. Michael10; Gøtze, Jens Peter9
1 Department of Clinical Medicine, Health, Aarhus University2 Department of Clinical Medicine - Department of Thoracic and Cardiovascular Surgery T, Department of Clinical Medicine, Health, Aarhus University3 Faculty Secretariat, The Faculty of Health Sciences, Health, Aarhus University4 Department of Clinical Medicine - Cardiovascular Research Unit, Department of Clinical Medicine, Health, Aarhus University5 Health, Aarhus University6 Cardiovascular Research Unit, Faculty of Health Sciences, Aarhus University, Aarhus University7 Cardiorenal Research Laboratory,The Mayo Clinic, MN8 dept. Clinical Biochemistry, Copenhagen University Hospital - Institut for Klinisk Medicin9 SUND ph.d. skole10 Department of Clinical Medicine, Health, Aarhus University11 Department of Clinical Medicine - Department of Thoracic and Cardiovascular Surgery T, Department of Clinical Medicine, Health, Aarhus University
Aim: Acute myocardial infarction causes neurohumoral activation characterized by increased sympathetic activity. CgA is a protein released during sympathoadrenal stress from neuroendocrine tissue. Recently, increased CgA concentrations in circulation have been reported and suggested to be an independent predictor of mortality after acute myocardial infarction. Materials & methods: Eighteen pigs underwent 1 h of regional myocardial ischemia followed by 3 h of reperfusion. Blood samples were collected every hour and plasma CgA was measured with two radioimmunoassays. Results: We found a 30% increase in plasma N-terminal CgA 1 h after re-establishment of coronary blood supply. On the other hand, plasma pancreastatin did not change in response to ischemia or reperfusion but decreased during the entire experiment. Conclusion: Our results suggest a differentiated CgA response in myocardial reperfusion after local cardiac anoxia that may reflect tissue-specific post-translational processing and release.
Biomarkers in Medicine, 2013, Vol 7, Issue 6, p. 959-967