Imam, Ayesha M2; Jin, Guang3; Sillesen, Martin4; Duggan, Michael3; Jepsen, Cecilie H3; Hwabejire, John O3; Lu, Jennifer3; Liu, Baoling3; Demoya, Marc A3; Velmahos, George C3; Alam, Hasan B3
1 Anæstesi- og operationsklinikken HOC, HovedOrtoCentret Rigshospitalet, Rigshospitalet, The Capital Region of Denmark2 From the Division of Trauma, Emergency Surgery and Surgical Critical Care, (A.M.I., G.J., M.S., M.D., C.H.J., J.O.H., J.L., M.A.D., G.C.V., H.B.A.), Department of Surgery, Massachusetts General Hospital/Harvard Medical School, Boston, Massachusetts; and Department of Surgery (G.J., B.L., H.B.A.), University of Michigan Hospital, Ann Arbor, Michigan.3 unknown4 Department of Anaesthesiology, Amager and Hvidovre Hospital, The Capital Region of Denmark
Combination of traumatic brain injury (TBI) and hemorrhagic shock (HS) can result in significant morbidity and mortality. We have previously shown that early administration of fresh frozen plasma (FFP) in a large animal model of TBI and HS reduces the size of the brain lesion as well as the associated edema. However, FFP is a perishable product that is not well suited for use in the austere prehospital settings. In this study, we tested whether a shelf-stable, low-volume, lyophilized plasma (LSP) product was as effective as FFP.
Journal of Trauma and Acute Care Surgery, 2013, Vol 75, Issue 6, p. 976-83