Imam, Ayesha M2; Jin, Guang3; Sillesen, Martin4; Duggan, Michael3; Jepsen, Cecilie H3; Hwabejire, John O3; Lu, Jennifer3; Liu, Baoling3; Demoya, Marc A3; Velmahos, George C3; Alam, Hasan B3
1 Anæstesi- og operationsklinikken HOC, HovedOrtoCentret Rigshospitalet, Rigshospitalet, The Capital Region of Denmark2 Brigham and Women's Hospital and Harvard Medical School3 unknown4 Kirurgisk Gastroenterologisk Klinik, Abdominal Centre, Rigshospitalet, The Capital Region of Denmark
Combination of traumatic brain injury (TBI) and hemorrhagic shock (HS) can result in significant morbidity and mortality. We have previously shown that early administration of fresh frozen plasma (FFP) in a large animal model of TBI and HS reduces the size of the brain lesion as well as the associated edema. However, FFP is a perishable product that is not well suited for use in the austere prehospital settings. In this study, we tested whether a shelf-stable, low-volume, lyophilized plasma (LSP) product was as effective as FFP.
Journal of Trauma and Acute Care Surgery, 2013, Vol 75, Issue 6, p. 976-83
Comparative Study; Journal Article; Research Support, U.S. Gov't, Non-P.H.S.