Hwabejire, John O2; Imam, Ayesha M3; Jin, Guang3; Liu, Baoling3; Li, Yongqing3; Sillesen, Martin4; Jepsen, Cecilie H3; Lu, Jennifer3; Demoya, Marc A3; Alam, Hasan B3
1 Anæstesi- og operationsklinikken HOC, HovedOrtoCentret Rigshospitalet, Rigshospitalet, The Capital Region of Denmark2 From the Division of Trauma, Emergency Surgery and Surgical Critical Care (J.O.H., A.M.I., G.J., B.L., Y.L., M.S., C.H.J., J.L., M.A.D., H.B.A.), Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts; and the Department of Surgery (G.J., B.L., H.B.A.), University of Michigan Hospital, Ann Arbor, Michigan.3 unknown4 Department of Anaesthesiology, Amager and Hvidovre Hospital, The Capital Region of Denmark
We have previously shown that the extent of traumatic brain injury (TBI) in large animal models can be reduced with early infusion of fresh frozen plasma (FFP), but the precise mechanisms remain unclear. In this study, we investigated whether resuscitation with FFP or normal saline differed in their effects on cerebral metabolism and excitotoxic secondary brain injury in a model of polytrauma, TBI, and hemorrhagic shock.
Journal of Trauma and Acute Care Surgery, 2013, Vol 75, Issue 6, p. 968-75