Compared to the conventional selective harmonic elimination-pulse width modulation (SHE-PWM), the selective harmonic elimination-pulse width and amplitude modulation (SHE-PWAM) control strategy results in significant improvements in the performance of CHB inverters. This fact is due to considering the optimization of the CHB dc sources’ values along with the optimized switching angles. This paper proposes a new SHE-PWAM control strategy and its realization in a drive application. Analysis and simulations are carried out on a fivelevel CHB inverter. Experimental verifications also validate the simulation results. The results demonstrate that the new SHEPWAM technique improves the performance of the drive compared to the conventional SHE-PWM.