1 Dermato-Venerologisk Afdeling og Videncenter for Sårheling (D/S), Bispebjerg and Frederiksberg Hospital, The Capital Region of Denmark2 Department of Dermatology, Bispebjerg Hospital, University of Copenhagen , Copenhagen , Denmark.
a patient series and overview of the literature
Otherwise healthy patients with severe recurrent mucocutaneous aphthous ulcerations (complex aphthosis) may require systemic immunomodulatory therapy. However, a subset of patients remain resistant or intolerant to recommended therapeutic agents. Recently, case reports have described that tumor necrosis factor-α (TNF-α) inhibitors may induce remission in these patients.
Journal of Dermatological Treatment, 2013, Vol 24, Issue 6, p. 444-6