Malin, Steven K2; Solomon, Thomas P J3; Blaszczak, Alecia4; Finnegan, Stephen4; Filion, Julianne4; Kirwan, John P4
1 Infektionsmedicinsk Klinik, Finsencentret, Rigshospitalet, The Capital Region of Denmark2 Department of Pathobiology, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio;3 Center for Aktiv Sundhed (CFAS), Finsencentret, Rigshospitalet, The Capital Region of Denmark4 unknown
Although some studies suggest that a linear dose-response relationship exists between exercise and insulin sensitivity, the exercise dose required to enhance pancreatic β-cell function is unknown. Thirty-five older obese adults with prediabetes underwent a progressive 12-wk supervised exercise intervention (5 days/wk for 60 min at ~85% HRmax). Insulin and C-peptide responses to an OGTT were used to define the first- and second-phase disposition index (DI; β-cell function = glucose-stimulated insulin secretion × clamp-derived insulin sensitivity). Maximum oxygen consumption (Vo2max) and body composition (dual-energy X-ray absorptiometry and computed tomography) were also measured before and after the intervention. Exercise dose was computed using Vo2/heart-rate derived linear regression equations. Subjects expended 474.5 ± 8.8 kcal/session (2,372.5 ± 44.1 kcal/wk) during the intervention and lost ~8% body weight. Exercise increased first- and second-phase DI (P 2,000 kcal/wk) are necessary to enhance β-cell function in adults with poor insulin secretion capacity.
American Journal of Physiology: Endocrinology and Metabolism, 2013, Vol 305, Issue 10
Clinical Trial; Journal Article; Research Support, N.I.H., Extramural; Adult; Aged; Exercise; Female; Humans; Insulin-Secreting Cells; Linear Models; Male; Middle Aged; Oxygen Consumption; Physical Education and Training; Prediabetic State; Time Factors; Weight Loss