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Classical swine fever virus infection modulates serum levels of INF-α, IL-8 and TNF-α in 6-month-old pigs

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Authors:
  • von Rosen, Tanya ;
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    Section for Virology, National Veterinary Institute, Technical University of Denmark
  • Lohse, Louise ;
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    Orcid logo0000-0002-6769-5447
    National Veterinary Institute, Technical University of Denmark
  • Nielsen, Jens ;
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    Section for Virology, National Veterinary Institute, Technical University of Denmark
  • Uttenthal, Åse
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    Section for Virology, National Veterinary Institute, Technical University of Denmark
DOI:
10.1016/j.rvsc.2013.09.011
Abstract:
Several studies have highlighted the important role of cytokines in disease development of classical swine fever virus (CSFV) infection. In the present study, we examined the kinetics of 7 porcine cytokines in serum from pigs infected with 3 different CSFV strains. Based on the clinical picture in 6-month-old Danish pigs, the strains used for inoculation were classified as being of low (Bergen), low to moderate (Eystrup) and moderate to high (Lithuania) virulence. The cytokines interferon-alpha (INF-α), interleukin-8 (IL-8) and tumor necrosis factor-alpha (TNF-α) showed increased levels after CSFV infection with more or less comparable course in the 3 groups. However, the cytokine level peaked with a 2–3 days delay in pigs infected with the low virulent strain compared to those infected with a moderately or highly virulent strain. These findings may indicate that INF-α, IL-8 and TNF-α are involved in the immune response during CSFV infection with strains of different virulence.
Type:
Journal article
Language:
English
Published in:
Research in Veterinary Science, 2013, Vol 95, Issue 3, p. 1262-1267
Keywords:
Cytokines; Pigs; Classical swine fever virus; Pathogenesis; Virulence; Pestivirus
Main Research Area:
Science/technology
Publication Status:
Published
Review type:
Peer Review
Submission year:
2013
Scientific Level:
Scientific
ID:
255248965

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