1 Department of Growth and Reproduction, Juliane Marie Centre, Rigshospitalet, The Capital Region of Denmark2 Klinisk Biokemisk Afdeling, Diagnostisk Center, Rigshospitalet, The Capital Region of Denmark3 Klinisk Genetisk Klinik, Juliane Marie Centre, Rigshospitalet, The Capital Region of Denmark
Pubertal gynaecomastia is a very common condition. Although the underlying etiology is poorly understood, it is generally accepted that excess of estrogens and/or deficit of androgens are involved in the pathogenesis. Furthermore, adiposity as well as the GH/IGF-I axis may play a role. In the present study we elucidate the association of adiposity and levels of FSH, LH, SHBG, testosterone, E2, IGF-I, and IGFBP-3 with the presence of pubertal gynaecomastia in a large cohort of healthy boys.
Clinical Endocrinology, 2014, Vol 80, Issue 5, p. 691-8