1 Department of Electrical Engineering, Technical University of Denmark2 Biomedical Engineering, Department of Electrical Engineering, Technical University of Denmark3 Centre de Recherche de l’Institut du Cerveau et de la Moelle épinière4 Hôpital Pitié-Salpêtrière5 Pierre and Marie Curie University - University of Paris VI6 CHRU Roger Salengro7 Copenhagen University Hospital
Background: Cathodal transcranial direct current stimulation (tDCS) of the right frontal cortex improves language abilities in post-stroke aphasic patients. Yet little is known about the effects of right frontal cathodal tDCS on normal language function. Objective/hypothesis: To explore the cathodal tDCS effects of the right-hemispheric homologue of Broca’s area on picture naming in healthy individuals. We hypothesized that cathodal tDCS improves Picture naming and that this effect is determined by the anatomical and functional connectivity of the targeted region. Methods: Cathodal and sham tDCS were applied to the right inferior frontal gyrus in 24 healthy subjects before a picture-naming task. All participants were studied with magnetic resonance imaging at pre-interventional baseline. Probabilistic tractography and dynamic causal modeling of functional brain activity during a word repetition task were applied to characterize anatomical and functional connectivity. Results: Subjects named pictures faster after cathodal relative to sham tDCS. The accelerating effect of tDCS was explained by a reduced frequency of very slow responses. tDCS-induced acceleration of Picture naming correlated with larger volumes of the tract connecting the right Broca’s area and the supplementary motor area (SMA) and greater functional coupling from the right SMA to the right Broca’s area. Conclusions: The results support the notion that the after-effects of tDCS on brain function are at least in part determined by the anatomical and functional connectivity of the targeted region.
Brain Stimulation, 2014, Vol 7, Issue 1, p. 122-129
Adult; Aged; Brain Mapping; Cross-Over Studies; Diffusion Tensor Imaging; Electric Stimulation; Electrodes; Female; Frontal Lobe; Humans; Image Processing, Computer-Assisted; Language; Male; Middle Aged; Motor Cortex; Neural Pathways; Young Adult; Diffusion tensor imaging; Functional magnetic resonance imaging; tDCS