de la Rica, Lorenzo3; Rodríguez-Ubreva, Javier4; García, Mireia4; Islam, Abul Bmmk4; Urquiza, José M4; Hernando, Henar4; Christensen, Jesper Aagaard5; Helin, Kristian5; Gómez-Vaquero, Carmen4; Ballestar, Esteban4
1 Helin Group, BRIC Research Groups, BRIC, Københavns Universitet2 Administration, BRIC Administration, BRIC, Københavns Universitet3 Chromatin and Disease Group, Cancer Epigenetics and Biology Programme (PEBC), Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet de Llobregat, Barcelona 08908, Spain. firstname.lastname@example.org unknown5 Helin Group, BRIC Research Groups, BRIC, Københavns Universitet
DNA methylation is a key epigenetic mechanism for driving and stabilizing cell-fate decisions. Local deposition and removal of DNA methylation are tightly coupled with transcription factor binding, although the relationship varies with the specific differentiation process. Conversion of monocytes to osteoclasts is a unique terminal differentiation process within the hematopoietic system. This differentiation model is relevant to autoimmune disease and cancer, and there is abundant knowledge on the sets of transcription factors involved.