Type 2 diabetes, obesity and insulin resistance are characterized by hypertriglyceridemia and ectopic accumulation of lipids in liver and skeletal muscle. AGPAT6 encodes a novel glycerol-3 phosphate acyltransferase, GPAT4, which catalyzes the first step in the de novo triglyceride synthesis. AGPAT6-deficient mice show lower weight and resistance to diet- and genetically induced obesity. Here, we examined whether common or low-frequency variants in AGPAT6 associate with type 2 diabetes or related metabolic traits in a Danish population.
B M C Medical Genetics, 2013, Vol 14, Issue 1
Journal Article; Research Support, Non-U.S. Gov't; Body Mass Index; Case-Control Studies; Denmark; Diabetes Mellitus, Type 2; Genetic Predisposition to Disease; Genotype; Glycerol-3-Phosphate O-Acyltransferase; Humans; Insulin; Insulin Resistance; Linkage Disequilibrium; Lipids; Obesity; Odds Ratio; Phenotype; Polymorphism, Single Nucleotide; Waist Circumference