Haddad, E M2; McAlister, V C2; Renouf, E2; Malthaner, R2; Kjaer, M S2; Gluud, L L3
1 Copenhagen Trial Unit, Cochranecenteret Rigshospitalet, Rigshospitalet, The Capital Region of Denmark2 unknown3 Gastrounit, Medical Division, Gastrounit, Amager and Hvidovre Hospital, The Capital Region of Denmark
Most liver transplant recipients receive either cyclosporin or tacrolimus to prevent rejection. Both drugs inhibit calcineurin phosphatase which is thought to be the mechanism of their anti-rejection effect and principle toxicities. The drugs have different pharmacokinetic profiles and potencies. Several randomised clinical trials have compared cyclosporin and tacrolimus in liver transplant recipients, but it remains unclear which is superior.
Cochrane Database of Systematic Reviews, 2006, Issue 4
Cyclosporine; Graft Rejection; Graft Survival; Humans; Immunosuppressive Agents; Liver Transplantation; Randomized Controlled Trials as Topic; Tacrolimus; Time Factors