Postnov, D. E.3; Neganova, A. Y.4; Jacobsen, J. C. B.4; von Holstein-Rathlou, Niels-Henrik4; Sosnovtseva, Olga4
1 Section of Renal and Vascular Research, Department of Biomedical Sciences, Faculty of Health and Medical Sciences, Københavns Universitet2 Saratov State University3 Saratov State University4 Section of Renal and Vascular Research, Department of Biomedical Sciences, Faculty of Health and Medical Sciences, Københavns Universitet
A case study in vasomotion
One consequence of cell-to-cell communication is the appearance of synchronized behavior, where many cells cooperate to generate new dynamical patterns. We present a simple functional model of vasomotion based on the concept of a two-mode oscillator with dual interactions: via relatively slow diffusive coupling that gives rise to wave dynamics and via fast changes in membrane potential that propagate almost instantly over significant distances. The model reproduces the basic calcium dynamics of the vascular smooth muscle cell: calcium waves which upon increased activity of cGMP-sensitive calcium-dependent chloride channels in the plasma membrane may synchronize into whole-cell oscillations which subsequently may spread across a large population of cells. We show how heterogeneity of the system can induce new patterns.
European Physical Journal. Special Topics, 2013, Vol 222, Issue 10, p. 2667-2676