Pap cytology is known to be more specific but less sensitive than testing for human papillomavirus (HPV) for the detection of high-grade cervical intraepithelial neoplasia (CIN2+). We assessed whether p16/Ki-67 dual-stained cytology, a biomarker combination indicative of transforming HPV infections, can provide high sensitivity for CIN2+ in screening while maintaining high specificity. Results were compared with Pap cytology and HPV testing.
National Cancer Institute. Journal (online), 2013, Vol 105, Issue 20, p. 1550-1557
Adult; Aged; Cell Transformation, Neoplastic; Cervical Intraepithelial Neoplasia; Colposcopy; Cytopathogenic Effect, Viral; Early Detection of Cancer; Europe; Female; Humans; Ki-67 Antigen; Mass Screening; Middle Aged; Neoplasm Grading; Neoplasm Proteins; Papillomaviridae; Papillomavirus Infections; Prospective Studies; Referral and Consultation; Sensitivity and Specificity; Tumor Markers, Biological; Uterine Cervical Neoplasms; Vaginal Smears