1 Institute of Pathology, Institute of Regional Health Research, Det Sundhedsvidenskabelige Fakultet, SDU2 Center Sønderjylland, Institute of Regional Health Research, Det Sundhedsvidenskabelige Fakultet, SDU3 PLEASE_CORRECT_ME4 unknown5 Institute of Pathology, Institute of Regional Health Research, Det Sundhedsvidenskabelige Fakultet, SDU
results of the PALMS study
Pap cytology is known to be more specific but less sensitive than testing for human papillomavirus (HPV) for the detection of high-grade cervical intraepithelial neoplasia (CIN2+). We assessed whether p16/Ki-67 dual-stained cytology, a biomarker combination indicative of transforming HPV infections, can provide high sensitivity for CIN2+ in screening while maintaining high specificity. Results were compared with Pap cytology and HPV testing.
National Cancer Institute. Journal (online), 2013, Vol 105, Issue 20, p. 1550-1557
Adult; Aged; Cell Transformation, Neoplastic; Cervical Intraepithelial Neoplasia; Colposcopy; Cytopathogenic Effect, Viral; Early Detection of Cancer; Europe; Female; Humans; Ki-67 Antigen; Mass Screening; Middle Aged; Neoplasm Grading; Neoplasm Proteins; Papillomaviridae; Papillomavirus Infections; Prospective Studies; Referral and Consultation; Sensitivity and Specificity; Tumor Markers, Biological; Uterine Cervical Neoplasms; Vaginal Smears