Effect of lifelong resveratrol supplementation and exercise training on skeletal muscle oxidative capacity in aging mice: impact of PGC-1α

Stine Ringholm; Jesper Olesen; Jesper Thorhauge Pedersen; Christina Tingbjerg Brandt; Jens Frey Halling; Ylva Hellsten; Clara Prats Gavalda; Henriette Pilegaard

doi:10.1016/j.exger.2013.08.012

Effect of lifelong resveratrol supplementation and exercise training on skeletal muscle oxidative capacity in aging mice

Authors:

Ringholm, Stine ;
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Molecular Integrative Physiology, Department of Biology, Faculty of Science, Københavns Universitet
Olesen, Jesper ;
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Molecular Integrative Physiology, Department of Biology, Faculty of Science, Københavns Universitet
Pedersen, Jesper Thorhauge ;
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Centre of Inflammation and Metabolism, The Center for Physical Activity Research and August Krogh Centre, Department of Biology, University of Copenhagen, Universitesparken 13, 2100, Copenhagen Ø, Denmark.
Brandt, Christina Tingbjerg ;
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Molecular Integrative Physiology, Department of Biology, Faculty of Science, Københavns Universitet
Halling, Jens Frey ;
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Centre of Inflammation and Metabolism, The Center for Physical Activity Research and August Krogh Centre, Department of Biology, University of Copenhagen, Universitesparken 13, 2100, Copenhagen Ø, Denmark.
Hellsten, Ylva ;
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0000-0002-2435-9558
Integrated Physiology, Department of Nutrition, Exercise and Sports, Faculty of Science, Københavns Universitet
Prats Gavalda, Clara ;
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Section of Systems Biology Research, Department of Biomedical Sciences, Faculty of Health and Medical Sciences, Københavns Universitet
Pilegaard, Henriette
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0000-0002-1071-0327
Molecular Integrative Physiology, Department of Biology, Faculty of Science, Københavns Universitet

Subtitle:

impact of PGC-1α

DOI:

10.1016/j.exger.2013.08.012

Abstract:

The present study tested the hypothesis that lifelong resveratrol (RSV) supplementation counteracts an age-associated decrease in skeletal muscle oxidative capacity through peroxisome proliferator-activated receptor-γ coactivator (PGC)-1α and that RSV combined with lifelong exercise training (ET) exerts additive effects through PGC-1α in mice.

Type:

Journal article

Language:

English

Published in:

Experimental Gerontology, 2013, Vol 48, Issue 11, p. 1311-1318

Keywords:

Journal Article; Research Support, Non-U.S. Gov't

Main Research Area:

Science/technology

Publication Status:

Published

Review type:

Peer Review

Submission year:

2013

Scientific Level:

Scientific

ID:

249761807

Effect of lifelong resveratrol supplementation and exercise training on skeletal muscle oxidative capacity in aging mice

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