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Effect of lifelong resveratrol supplementation and exercise training on skeletal muscle oxidative capacity in aging mice

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Authors:
  • Ringholm, Stine ;
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    Molecular Integrative Physiology, Department of Biology, Faculty of Science, Københavns Universitet
  • Olesen, Jesper ;
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    Molecular Integrative Physiology, Department of Biology, Faculty of Science, Københavns Universitet
  • Pedersen, Jesper Thorhauge ;
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    Centre of Inflammation and Metabolism, The Center for Physical Activity Research and August Krogh Centre, Department of Biology, University of Copenhagen, Universitesparken 13, 2100, Copenhagen Ø, Denmark.
  • Brandt, Christina Tingbjerg ;
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    Molecular Integrative Physiology, Department of Biology, Faculty of Science, Københavns Universitet
  • Halling, Jens Frey ;
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    Centre of Inflammation and Metabolism, The Center for Physical Activity Research and August Krogh Centre, Department of Biology, University of Copenhagen, Universitesparken 13, 2100, Copenhagen Ø, Denmark.
  • Hellsten, Ylva ;
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    Orcid logo0000-0002-2435-9558
    Integrated Physiology, Department of Nutrition, Exercise and Sports, Faculty of Science, Københavns Universitet
  • Prats Gavalda, Clara ;
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    Systems Biology Research, Department of Biomedical Sciences, Faculty of Health and Medical Sciences, Københavns Universitet
  • Pilegaard, Henriette
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    Orcid logo0000-0002-1071-0327
    Molecular Integrative Physiology, Department of Biology, Faculty of Science, Københavns Universitet
Subtitle:
impact of PGC-1α
DOI:
10.1016/j.exger.2013.08.012
Abstract:
The present study tested the hypothesis that lifelong resveratrol (RSV) supplementation counteracts an age-associated decrease in skeletal muscle oxidative capacity through peroxisome proliferator-activated receptor-γ coactivator (PGC)-1α and that RSV combined with lifelong exercise training (ET) exerts additive effects through PGC-1α in mice.
Type:
Journal article
Language:
English
Published in:
Experimental Gerontology, 2013, Vol 48, Issue 11, p. 1311-1318
Keywords:
Journal Article; Research Support, Non-U.S. Gov't
Main Research Area:
Science/technology
Publication Status:
Published
Review type:
Peer Review
Submission year:
2013
Scientific Level:
Scientific
ID:
249761807

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