Age-related metabolic diseases are often associated with low-grade inflammation. The aim of the present study was to investigate the role of the transcriptional co-activator PGC-1α in the potential beneficial effects of exercise training and/or resveratrol in the prevention of age-associated low-grade inflammation. To address this, a long-term voluntary exercise training and resveratrol supplementation study was conducted.
Experimental Gerontology, 2013, Vol 48, Issue 11, p. 1274-1284
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Aging; Low-grade inflammation; Exercise training; Resveratrol; PGC-1 alpha